Effect of riboflavin deficiency on activity of NADH-FMN oxidoreductase (ferriductase) and iron content of rat liver.

who postulated that the inhibitor initially acts in a reversible competitive manner, but is then converted into fluoroaconitate which alkylates the active site of the enzyme.] Comparison of the LDSo values for fluoroacetate with the concentrations of it which inhibit hepatic respiration suggests that in neither species is the liver the critical organ. Nevertheless, it is tempting to speculate that trout are relatively immune to fluoroacetate partly because their aconitate hydratase is only poorly inhibited by fluorocitrate, and partly because their low body temperature further diminishes the potency of this inhibitor.